Hypoclorous acid, or HOCl (sometimes called neutral electrolysed water or super-oxidized solution), is a natural and effective solution for disinfecting and cleaning, which can reduce the spread of infectious diseases.
It’s the original disinfectant.
HOCl is produced by white blood cells within the bodies of all mammals (humans included). At the right concentrations (see below), it’s really good at killing harmful viruses, bacteria, and fungi. Which means that regular disinfecting with HOCl can help prevent the spread of harmful bugs and viruses to keep communities healthier.
It’s safe.
HOCl is a non-toxic and environmentally friendly alternative to traditional disinfectants like bleach and ammonia. It can be used on various surfaces, including fabrics, plastics, metals, and skin. It’s widely used in hospitals, offices, and restaurants, and nasal sprays to fight COVID-19.
It’s has many proven uses.
When it comes to hygiene, HOCl is used to sanitize surfaces and disinfect the air. It’s also widely used for mouth care, wound care, skin care, eye care and veterinary care. It’s approved as a no-rinse sanitizer for washing organic food. It even reduces compost odor and kills pests and black mold.
No wonder it has been called a miracle liquid.
We know, it sounds too good to be true. We thought so too. But this stuff really does work.
Of course there are caveats and cautions. Though many uses have been approved by regulatory agencies like the FDA and EPA, it’s important understand these:
Some example uses and their associated concentrations
At lower pH levels (more acidic conditions), HOCl is favored over the hypochlorite ion (OCl-), which is its less effective form. As the pH increases, the equilibrium shifts towards the formation of the hypochlorite ion.
Maintaining a pH level within the recommended range ensures that a higher proportion of the chlorine is present as HOCl, which is the more potent and effective disinfecting form.
For specific applications, especially medical or industrial settings, it's advisable to consult the manufacturer's guidelines or relevant regulatory standards to ensure the correct pH level for optimal disinfection performance.
Finally, how to make it at home:
And where to buy it:
Videos
Research
Name | Summary | Key Points | Source |
|---|---|---|---|
A new sprayable solution containing hypochlorous acid has been shown to effectively kill the SARS-CoV-2 virus, offering a promising method for improving hygiene in the upper respiratory tract. | - AOS2020, a sprayable solution with hypochlorous acid, shows over 99.8% effectiveness against SARS-CoV-2 in under 1 minute. - The solution is non-irritating to nasal and oral mucosa. - AOS2020 could potentially reduce viral load in the upper respiratory tract, aiding in COVID-19 treatment. - Further clinical trials are needed to confirm its effectiveness and safety. | This is from European Archives of Oto-Rhino-Laryngology in 2023 at https://link.springer.com/article/10.1007/s00405-021-06644-5 | |
This study found that hypochlorous acid solution did not effectively kill bacteria in the nasal discharge of patients with chronic rhinosinusitis after soaking for one or five minutes, suggesting that longer exposure might be necessary for antibacterial effects. | - Hypochlorous acid (HOCl) solution did not show significant antibacterial effects on nasal discharge from chronic rhinosinusitis (CRS) patients within 5 minutes. - Bacterial culture rates were similar for HOCl, normal saline, and povidone-iodine solutions. - Alcohol showed better antibacterial activity but still had limitations. - Longer exposure times may be necessary to observe antibacterial effects of HOCl and other solutions. - Further studies are needed to explore the effectiveness of longer soaking durations. | This is from the International Journal of Otolaryngology in 2023 at https://www.hindawi.com/journals/ijoto/2018/8568694/ | |
This study shows that non-white blood cells can enhance their ability to fight viruses by using chloride ions to produce a substance called hypochlorous acid, which helps inhibit various types of viral infections. | - Non-myeloid cells can enhance antiviral responses using chloride ions. - Increased sodium chloride (NaCl) levels boost the production of hypochlorous acid (HOCl), which has antiviral properties. - HOCl inhibits a variety of viruses, including DNA and RNA viruses. - The antiviral mechanism relies on intracellular chloride and is not a direct effect of NaCl on viruses. - This research suggests potential therapeutic applications of NaCl in treating viral infections. | This is from Scientific Reports in 2018 at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134045/ | |
A study found that hypochlorous acid nasal spray may be a convenient alternative to saline nasal irrigation for patients recovering from sinus surgery, showing similar effectiveness in improving symptoms of chronic rhinosinusitis. | - HOCl nasal spray is as effective as saline nasal irrigation for CRS patients post-FESS. - Significant reduction in endoscopic scores with HOCl nasal spray. - NS nasal irrigation significantly reduced TWSNOT-22 scores. - HOCl nasal spray is convenient and could be a viable alternative to saline irrigation. | This is from Am J Otolaryngol in 2022 at https://ciplamed-library.com/content/can-hypochlorous-acid-nasal-spray-be-an-alternative-to-saline-nasal-irrigation-in-crs | |
A study found that slightly acidic hypochlorous acid (HOCl) mouthwash is more effective than chlorhexidine (CHX) mouthwash in reducing bad breath and bacterial activity in the mouth, making it a safer and more pleasant option for oral care. | - HOCl mouthwash is effective in reducing halitosis and dental plaque compared to CHX. - HOCl shows significant decreases in harmful bacteria associated with periodontal diseases. - CHX has side effects like strong taste and tooth discoloration, making it less convenient. - HOCl is safe for long-term use and has strong disinfectant properties. - Using HOCl can improve oral health and prevent dental diseases more effectively than CHX. | This is from Journal in 2023 at https://www.alliedacademies.org/articles/comparison-of-the-preventive-effects-of-slightly-acidic-hocl-mouthwash-and-chx-mouthwash-for-oral-diseases-10156.html | |
A nasal spray containing hypochlorous acid may be a convenient alternative to traditional saline irrigation for patients recovering from sinus surgery, as it showed similar benefits in reducing symptoms and improving health outcomes. | - HOCl nasal spray is effective as an alternative to normal saline nasal irrigation after sinus surgery. - Both treatments showed benefits, but HOCl spray is more convenient for patients. - Further research is needed to explore long-term effects of HOCl on nasal health. | This is from Journal in 2023 at https://www.sciencedirect.com/science/article/abs/pii/S0196070921003653 | |
A low concentration solution of hypochlorous acid can effectively kill bacteria, fungi, and viruses, making it a useful option for nasal irrigation in patients with chronic sinusitis. | - Low concentration hypochlorous acid (HOCl) is effective for nasal irrigation. - It shows over 99% bactericidal and fungicidal activity for most tested microorganisms. - No toxicity observed in human nasal cells after treatment. - Significant reduction in human influenza A virus was achieved. | This is from Journal in 2023 at https://onlinelibrary.wiley.com/doi/abs/10.1097/MLG.0b013e31817f4d34 | |
The Sentinox spray, which contains hypochlorous acid, has been shown to significantly reduce viral loads in mild COVID-19 patients and effectively kill various respiratory viruses, suggesting it could be a useful tool for managing infections. | - Sentinox spray reduces viral load in mild COVID-19 patients. - Significant reduction observed in patients with medium viral loads. - Spray is safe and well-tolerated with few side effects. - High virucidal activity against various respiratory viruses. - Potential for use in preventing respiratory infections. | This is from Viruses in 2022 at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144724/ | |
Hypochlorous acid (HOCl) is a highly effective, safe, and cost-efficient disinfectant that can significantly improve cleaning processes in healthcare environments, yet it remains underutilized compared to traditional disinfectants like bleach. | - Hypochlorous acid (HOCl) is a powerful, safe disinfectant. - It is effective against a wide range of pathogens, including superbugs. - HOCl can be generated on-site, reducing costs and improving efficiency. - It is environmentally friendly and safe for patients and staff. - Hospitals should consider using HOCl to enhance infection prevention efforts. - Current disinfectants may not be the safest or most effective options available. | This is from Health Facilities Management in 2023 at https://www.hfmmagazine.com/articles/4458-exploring-the-use-of-hypochlorous-acid-for-disinfection | |
Hypochlorous Acid (HOCl) is a powerful and safe disinfectant that effectively kills a wide range of pathogens, including the coronavirus, making it a valuable tool for wound care and infection control. | - Hypochlorous Acid (HOCl) is an effective disinfectant and antiseptic. - It is safe for human use and poses no risk of resistance. - HOCl can enhance wound healing and reduce infection rates. - It is environmentally friendly, breaking down into water and salt. - Current manufacturing allows for affordable, large-scale production. - HOCl is approved for various medical and food safety applications. - It can significantly reduce healthcare costs associated with wound care. | This is from Brio in 2023 at https://www.who.int/groups/expert-committee-on-selection-and-use-of-essential-medicines/23rd-expert-committee/a18-hypochlorous | |
Hypochlorous acid, at a concentration of 0.01%, has been shown to effectively kill the SARS-CoV-2 virus and could be used as an antiseptic to help prevent COVID-19 infection through mucous membranes in the eyes, nose, and mouth. | - 0.01% hypochlorous acid is effective as an antiseptic against SARS-CoV-2. - It can be used on the eyes, nose, and mouth to prevent COVID-19 infection. - Recommended for healthcare protocols and general public use to reduce viral load. - Further studies needed to confirm effectiveness and safety. | This is from Arch Soc Esp Oftalmol in 2023 at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8598944/ | |
A study found that while low-concentration hypochlorous acid nasal irrigation can reduce allergic rhinitis symptoms, it is no more effective than regular saline nasal irrigation. | - Low-concentration hypochlorous acid (HOCl) nasal irrigation reduces allergic rhinitis symptoms. - No significant side effects were reported with HOCl use. - HOCl did not show additional benefits compared to saline nasal irrigation. - Both treatments improved symptoms over the study period. | This is from Journal in 2023 at https://pubmed.ncbi.nlm.nih.gov/34236253/ | |
The study highlights that aerosolized hypochlorous acid is a safe and effective disinfectant against bacteria and viruses, making it a promising option for sanitizing indoor environments without harming human health. | - Aerosolized hypochlorous acid (HOCl) is effective in killing bacteria and viruses. - At 300 ppm, HOCl is safe for human tissues and does not affect cell viability. - It shows significant bactericidal (up to 99.9% reduction) and virucidal effects on various surfaces. - HOCl can be produced on-site, making it low-cost and environmentally friendly. - The study supports HOCl as a promising disinfectant for indoor environments, especially during pandemics. | This is from International Journal of Environmental Research and Public Health in 2022 at https://www.mdpi.com/1660-4601/19/20/13163 | |
Inhaling mist made from hypochlorous acid (HOCl) has shown promise in rapidly inactivating respiratory viruses like SARS-CoV-2 without adverse effects in experimental studies or in self-reported experiences from essential workers during the pandemic. | - Inhalation of hypochlorous acid (HOCl) can effectively inactivate SARS-CoV-2 and other respiratory viruses. - No significant adverse effects were observed in animals exposed to aerosolized HOCl. - Human subjects reported minor, transient side effects after inhaling HOCl, with some noting improved respiratory symptoms. - HOCl shows potential as a safe disinfectant and therapeutic agent against respiratory infections. - The study highlights the need for further evaluation of HOCl's long-term effects and its use in public health settings. | This is from Research Square in 2023 at https://europepmc.org/article/PPR/PPR411633 | |
Inhaling microaerosolized hypochlorous acid (HOCl) has been shown to effectively inactivate respiratory viruses like SARS-CoV-2 without causing harm to lung tissues, suggesting its potential as a safe and accessible treatment option during the pandemic. | - Inhalation of microaerosolized hypochlorous acid (HOCl) shows potential benefits in preventing and treating respiratory virus infections, including COVID-19. - HOCl rapidly inactivates SARS-CoV-2 and other viruses in laboratory settings. - No adverse effects were observed in animals exposed to HOCl, indicating its safety for pulmonary use. - Human exposure to HOCl mist during the pandemic showed no serious issues, with only minor, transient effects reported. - HOCl may serve as an effective, inexpensive, and accessible method for respiratory infection prevention. | This is from Archives of Internal Medicine Research in 2023 at https://fortuneonline.org/articles/inhalation-of-microaerosolized-hypochlorous-acid-hocl-biochemical-antimicrobial-and-pathological-assessment.html | |
A study found that using low-concentration hypochlorous acid for nasal irrigation significantly improved symptoms in patients with chronic sinusitis who did not respond to other treatments, compared to saline solution. | - Low-concentration hypochlorous acid (HOCl) nasal irrigation improves symptoms of chronic rhinosinusitis (CRS) better than saline irrigation. - Significant symptom relief was observed in patients using HOCl after 2 and 4 weeks of treatment. - No significant adverse effects were reported from HOCl nasal irrigation. - HOCl may serve as an effective adjunct therapy for patients with CRS who do not respond to standard medical treatments. | This is from Journal in 2016 at https://pubmed.ncbi.nlm.nih.gov/27853946/ | |
Hypochlorous acid (HOCl) is a natural part of our immune system that helps fight germs and promotes healing without causing irritation, making it safe for use on both humans and animals. | - HOCl is a natural part of the body's defense system, produced by white blood cells. - It fights germs and stimulates healing. - Non-hazardous for humans and animals; no adverse effects. - Effective in reducing inflammation and enhancing healing. - Can mitigate scarring and clear skin issues. - Historically underused despite evidence of efficacy in healing and disinfection. | This is from Journal in 2023 at https://www.brioglobal.com/pages/science | |
Hypochlorous acid is an effective, safe, and inexpensive disinfectant that can help combat the spread of COVID-19 in medical and dental settings. | - Hypochlorous acid (HOCl) is an effective, nontoxic disinfectant against COVID-19. - It can be produced on-site easily and economically. - HOCl is safe for use in dental and medical settings. - Effective in inactivating various viruses, including coronaviruses, in under a minute. - Recommended for surface disinfection, hand sanitizing, and as a mouth rinse. - Stability and efficacy can be affected by exposure to light and temperature. | This is from Journal of Oral and Maxillofacial Surgery in 2023 at https://www.joms.org/article/S0278-2391(20)30672-8/fulltext | |
Hypochlorous acid (HOCL) is a powerful, natural disinfectant produced by the human body that effectively fights infections and can be safely used for various cleaning and health applications. | - Hypochlorous acid (HOCL) is effective against infections and is produced naturally by the body. - It has multiple mechanisms to kill bacteria and viruses. - Stabilized HOCL can be produced and used safely as a disinfectant. - It penetrates biofilms, making it effective for treating periodontal disease. - HOCL is safe for various applications, including oral care and wound healing. - It is recognized as Generally Regarded as Safe (GRAS) by the FDA. | This is from Catalyst in 2023 at https://www.burkhartdental.com/hypochlorous-acid-hocl-not-novel-but-essential/ | |
Hypochlorous acid, known as "The Miracle Molecule," is a powerful skincare ingredient that helps treat various skin issues, supports the body's natural defenses, and is suitable for all skin types, including sensitive skin. | - Hypochlorous acid (HOCl) is a natural immune molecule produced by the body. - Effective against bacteria, viruses, and fungi, making it suitable for all skin types. - Helps reduce blemishes, treat acne, soothe eczema, and reverse signs of aging. - Supports skin's natural defenses without harming its microbiome. - Aids in treating dermatitis caused by mask-wearing. - Ensures maximum benefits when manufactured under medical-grade conditions. - Anti-inflammatory and immune-modulatory effects beneficial for chronic skin conditions. - Used by dermatologists to prepare skin for treatments and assist post-procedure healing. | This is from Journal in 2023 at https://thoclor.com/benefits-hocl/?v=e4dd286dc7d7 | |
Hypochlorous acid is a gentle yet effective disinfectant that can help protect against COVID-19 and improve skin conditions like acne and maskne, making it a versatile choice for skincare and sanitization. | - Hypochlorous acid (HOCl) is an antimicrobial and anti-inflammatory substance made by white blood cells. - It can disinfect skin and help treat conditions like acne, psoriasis, and eczema. - Effective against COVID-19, listed by the EPA as a virus killer. - Safe for sensitive skin; does not sting or burn. - Recommended for use on skin and masks to prevent "maskne." - Available in products like Lasercyn Dermal Spray and Stamina Cosmetics Maskne Calming Mist. - Acts as a gentler alternative to alcohol-based hand sanitizers. | This is from NewBeauty in 2023 at https://www.newbeauty.com/hypochlorous-acid-skin-care/ | |
A study is being conducted to assess the effectiveness and safety of a hypochlorous acid spray for treating COVID-19 patients, comparing it to a placebo treatment. | - Study evaluates hypochlorous acid spray for COVID-19 treatment. - Conducted in Tunisia with 400 participants. - Randomized, controlled, double-blind design. - Primary goal: assess change in viral load after 3 days. - Secondary goals: symptom duration, hospitalization needs, and contamination rates. - Participants must be 18+, symptomatic, and test positive for SARS-CoV-2. - Excludes those with allergies to hypochlorous acid or severe health issues. | This is from Journal in 2023 at https://clinicaltrials.gov/ct2/show/NCT05862480 | |
The study proposes using hypochlorous acid as a nasal spray to help protect healthcare workers at high risk of COVID-19 infection, showing promise in reducing viral load and enhancing safety. | - Hypochlorous acid (HClO) is proposed as a nasal spray for preventing SARS-CoV-2 infection in healthcare workers. - HClO is a safe and effective antimicrobial solution, reducing viral load without harming human cells. - The study aims to evaluate the safety and efficacy of HClO compared to a placebo in high-risk health personnel. - The trial is randomized, double-masked, and placebo-controlled. - Expected study completion date is August 15, 2021. | This is from Journal in 2023 at https://clinicaltrials.gov/ct2/show/NCT04684550 | |
This patent describes a new method to use safe and effective products like hypochlorous acid and superoxidized water to combat harmful germs and infections. | - Non-toxic antimicrobial agents can effectively treat infections caused by various pathogens. - The invention focuses on using oxychlorine compounds, including hypochlorous acid and superoxidized water. - These agents can be administered via multiple routes, including aerosol and topical applications. - The system aims to prevent, treat, and reduce harmful effects from pathogenic microorganisms. - It addresses the need for safe and effective treatments with minimal toxicity. - The invention is applicable for both human and veterinary use. | This is from Journal in 2023 at https://patents.google.com/patent/WO2010025305A1/en | |
Hypochlorous acid is a powerful yet gentle disinfectant that can help treat acne, speed up wound healing, and reduce inflammation, making it safe for sensitive skin. | - Hypochlorous acid (HOCl) is effective against bacteria and acne. - It is naturally produced by the body and is safe for sensitive skin. - HOCl speeds up wound healing and combats inflammation. - Available in sprays, creams, and serums for skin care. - Not a substitute for washing; serves as an additional defense. - Verify product safety and avoid those with fragrance if sensitive. | This is from Journal in 2023 at https://health.clevelandclinic.org/hypochlorous-acid-skin-care/ | |
Hypochlorous acid is a versatile and safe topical treatment that can help with wound care, infection prevention, and managing skin conditions like atopic dermatitis and acne. | - Hypochlorous acid (HClO) is effective for infection prevention and wound care. - It promotes healing and reduces scarring. - Useful for inflammatory skin conditions like atopic dermatitis and pruritus. - Exhibits antimicrobial properties with low toxicity to skin cells. - Emerging research suggests benefits for acne and seborrheic dermatitis. - Generally well-tolerated with a good safety profile. | This is from Journal in 2025 at https://jintegrativederm.org/doi/10.64550/joid.1d4y5r09 | |
The EPA has exempted hypochlorous acid from pesticide residue tolerance requirements when used on food-contact surfaces in public eating places, allowing for safer use in food handling without the risk of harmful residues. | - EPA exempts hypochlorous acid residues from tolerance requirements for food-contact surfaces in public eating places. - Effective date: September 14, 2022. - No comments were received on the proposal; exemption finalized. - Exemption ensures no harm from aggregate exposure, including to infants and children. - Limit set at 200 ppm total available chlorine for hypochlorous acid use. | This is from Federal Register in 2022 at https://www.federalregister.gov/documents/2022/09/14/2022-19799/hypochlorous-acid-exemption-from-the-requirement-of-a-tolerance | |
Hypochlorous acid (HOCl) is being considered as a safe and effective treatment for respiratory infections, including viruses like COVID-19, due to its broad antimicrobial properties and low toxicity. | - Hypochlorous acid (HOCl) is a promising respiratory antiseptic. - It may effectively treat bacterial and viral infections, including COVID-19. - HOCl has low toxicity and is part of the body's immune system. - It can be produced easily and is cost-effective. - Research supports its use in inhalation therapies for respiratory health. - Ongoing studies are evaluating its clinical efficacy and safety. | This is from Viruses in 2025 at https://www.mdpi.com/1999-4915/17/9/1219 | |
Hypochlorous acid (HOCl) is being explored as a safe and effective respiratory antiseptic that could help combat infections like COVID-19 by reducing harmful bacteria and viruses in the respiratory tract. | - Hypochlorous acid (HOCl) is a promising respiratory antiseptic. - It can combat bacterial and viral infections, including SARS-CoV-2. - HOCl is low in toxicity and effective against a broad spectrum of pathogens. - Inhalation of HOCl may be beneficial for respiratory health. - Ongoing studies are evaluating its efficacy in clinical settings. | This is from Viruses in 2025 at https://www.mdpi.com/1999-4915/17/9/1219 | |
Sodium Dichloroisocyanurate (NaDCC) is a highly effective disinfectant that works by releasing hypochlorous acid in water, which effectively kills a wide range of harmful microorganisms while remaining stable and active for extended periods. | - NaDCC is a powerful disinfectant due to its ability to generate hypochlorous acid (HOCl). - HOCl effectively kills a wide range of microorganisms, including bacteria, viruses, and fungi. - NaDCC is stable in solid form, ensuring potency until use. - It offers a controlled release of HOCl, maintaining disinfectant activity over time. - NaDCC performs well across various pH levels, enhancing its effectiveness in different water conditions. | This is from Journal in 2025 at https://www.nbinno.com/article/water-treatment-agents/science-behind-nadcc-powerful-disinfectant-wq | |
A study found that while low-concentration hypochlorous acid nasal irrigation can reduce allergic rhinitis symptoms, it is no more effective than saline nasal irrigation. | - Hypochlorous acid (HOCl) nasal irrigation reduces allergic rhinitis symptoms. - No significant side effects were reported with HOCl use. - HOCl showed no additional benefit compared to saline nasal irrigation. - Both treatments improved symptoms over four weeks. | This is from Journal in 2025 at https://pubmed.ncbi.nlm.nih.gov/34236253/ | |
A study found that using a hypochlorous acid nasal rinse can safely help reduce symptoms in patients with COVID-19 who are not hospitalized. | - Intranasal lavage with hypochlorous acid may safely reduce COVID-19 symptoms in outpatients. - Study involved 88 patients, with 74 completing the treatment. - No patients required mechanical ventilation; no deaths occurred. - Mild side effects included nasal burning and metallic taste. - Further research is needed to confirm effectiveness and explore broader applications. | This is from Journal in 2025 at https://www.medrxiv.org/content/10.1101/2023.07.17.23292426v1.full-text | |
A study found that nasal irrigation with low concentrations of hypochlorous acid can reduce allergic rhinitis symptoms, but it does not work better than saline nasal irrigation. | - Low-concentration hypochlorous acid (HOCl) nasal irrigation reduces allergic rhinitis symptoms. - No significant side effects were observed with HOCl treatment. - HOCl showed no additional benefit compared to saline nasal irrigation. - Both HOCl and saline groups experienced similar improvements in symptoms. | This is from Journal in 2025 at https://pubmed.ncbi.nlm.nih.gov/34236253/ | |
This study found that hypochlorous acid and hypochlorite mists effectively kill airborne influenza virus particles without causing significant harm to animals when inhaled. | - Hypochlorous acid gas effectively kills influenza A virus aerosols. - A concentration of 1 vol. gas in 2 million vol. air can destroy 99% of virus particles. - No significant toxic effects observed in mice and cats from inhaling the gas. - Acute irritation of mucous membranes noted, but no increased susceptibility to influenza infection. | This is from Journal of Hygiene in 2024 at https://www.cambridge.org/core/journals/epidemiology-and-infection/article/studies-on-airborne-virus-infections-iii-the-killing-of-aerial-suspensions-of-influenza-virus-by-hypochlorous-acid/FED980BCC43BD8CD785AA70C05115496 | |
Hypochlorous acid is a powerful and safe disinfectant that can effectively combat antibiotic-resistant pathogens without harming human tissues or the environment. | - Hypochlorous acid (HOCl) is an effective disinfectant against resistant pathogens. - It is safe for human tissues and environmentally friendly. - Stable HOCl can be produced without toxic waste. - HOCl shows promise in controlling infections, including prions. - Its use can enhance infection control in healthcare settings. - Adoption of HOCl can address gaps in traditional sterilization methods. | This is from Journal in 2024 at https://infectioncontrol.tips/2017/10/06/hypochlorous-innate-response/ | |
This study demonstrates that electrolyzed hypochlorous acid (HOCl) is an effective and eco-friendly solution for cleaning and sanitizing floors, offering similar cleaning performance to traditional detergents while reducing environmental impact. | - Electrolyzed hypochlorous acid (HOCl) is effective for floor cleaning and sanitation. - It reduces organic dirt and microbial charge significantly. - No chemical residues are left on surfaces after use. - HOCl does not damage floor materials, even after multiple applications. - The system is eco-friendly, reducing CO2 emissions by about 30% compared to traditional detergents. - It is safe, easy to use, and cost-effective for large area disinfection. | This is from the International Journal of Environmental Research and Public Health in 2023 at https://www.mdpi.com/1660-4601/20/18/6712 | |
Hypochlorous acid is a skincare ingredient with a long history of use for wound care and infections, showing promise for treating conditions like acne and atopic dermatitis, but its effectiveness in over-the-counter products may vary due to stability issues and lack of rigorous studies. | - Hypochlorous acid (HOCl) is gaining popularity in skincare but has a long history as a wound disinfectant. - It has FDA approval for various medical uses, including wound care and infection management. - HOCl is effective in reducing microbial load in wounds and may aid in wound healing. - It shows promise in treating atopic dermatitis and acne, with some studies indicating similar efficacy to traditional treatments. - Stability of HOCl is crucial for its effectiveness; environmental factors can significantly affect it. - Over-the-counter HOCl products may vary in efficacy and stability compared to prescription formulations. - More research is needed to fully understand the effectiveness and stability of OTC HOCl products. | This is from Journal of Drugs in Dermatology in 2024 at https://jddonline.com/articles/hypochlorous-acid-blast-past-S1545961624P1024X/ | |
The study found that hypochlorous acid water is effective at killing the SARS-CoV-2 virus, making it a promising disinfectant for reducing the spread of COVID-19 in various environments. | - Cryptosporidium is commonly found in Minnesota public supply wells, with 40% showing at least one detection. - Risk factors for Cryptosporidium contamination include well depth, runoff catchment area, and land use. - Shallower wells and higher impervious surfaces increase contamination risk. - Variability in chemical parameters, like bromide and nitrate, correlates with higher Cryptosporidium detection. - Traditional practices and gender norms significantly impact women's access to water in the studied communities. - Public health interventions are needed to improve water quality and access. | This is from Journal Water Health in 2024 at https://iwaponline.com/jwh/article/22/3/601/100428/Virucidal-efficacy-of-hypochlorous-acid-water-for | |
Hypochlorous acid is a safer and more effective disinfectant compared to traditional bleach (sodium hypochlorite) because it penetrates cell walls easily and does not repel germs, making it a better choice for cleaning. | - Hypochlorous acid (HOCl) is 80 to 120 times more effective than sodium hypochlorite (bleach). - HOCl has no charge, allowing it to penetrate cell walls of germs more easily. - Higher pH levels decrease the effectiveness of HOCl. - HOCl has a pH similar to water, tricking germs into allowing it inside. - Sodium hypochlorite (bleach) can be effective but is unsafe to handle due to its high pH. - Bleach can cause adverse effects on health and materials. | This is from Journal in 2024 at https://annihilare.com/disinfection-with-hypochlorous-vs-sodium-hypochlorite-traditional-bleach/ | |
A new cleaning method using hypochlorous acid is more effective and safer than traditional methods for disinfecting gastrointestinal endoscopy procedure rooms, significantly reducing harmful bacteria levels. | - HOCl cleaning and disinfection is more effective than standard methods in GI endoscopic procedure rooms. - HOCl reduces ATP scores significantly after procedures. - Misting with HOCl further improves cleaning results. | This is from Journal in 2024 at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255518/ | |
Chlorine-based disinfectants, specifically hypochlorous acid (HOCl) and hypochlorite (OCl-), have different properties and uses, and it's crucial to understand these differences to ensure safe and effective disinfection in clinical settings. | - HOCl (hypochlorous acid) and OCl- (hypochlorite) are both used for disinfection but have different properties and uses. - Understanding the pH of chlorine solutions is crucial as it affects the effectiveness and safety of the disinfectant. - Misuse of chlorine solutions can lead to harmful outcomes, including skin burns and toxic gas release. - Clear terminology is essential to avoid confusion and ensure safe use of disinfectants in clinical settings. - Proper storage and handling of disinfectants are important to maintain their efficacy and safety. | This is from Journal in 2024 at https://www.joghr.org/article/84488-hocl-vs-ocl-clarification-on-chlorine-based-disinfectants-used-within-clinical-settings?t=&utm_source=perplexity | |
A study found that hypochlorous acid is as effective as chlorhexidine in reducing harmful bacteria after periodontal surgery, making it a promising option for post-surgical care with fewer side effects. | - Hypochlorous acid (HOCl) is as effective as chlorhexidine (CHX) in reducing plaque and bacterial recolonization after periodontal surgery. - HOCl shows low adverse effects compared to CHX. - Both treatments improve periodontal healing, but HOCl may lead to better clinical attachment gains over time. - HOCl is a promising alternative for post-surgical plaque control without significant toxicity. | This is from Journal in 2023 at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10451621/ | |
Hypochlorous acid is a promising alternative to traditional antibiotics due to its effectiveness against a wide range of germs without causing antibiotic resistance or harming human cells. | - Hypochlorous acid (HOCl) is a promising alternative to conventional antibiotics due to its broad-spectrum antimicrobial activity. - It effectively kills bacteria, viruses, and fungi without promoting antibiotic resistance. - HOCl is non-toxic to human cells and has a low potential for side effects. - It has been successfully used in clinical applications like wound care and infection control. - Further research is needed to optimize its delivery methods and understand its mechanisms of action. | This is from Journal in 2023 at https://www.microbiochemjournal.com/articles/ijcmbt-aid1026.php | |
A study found that exposure to hypochlorous acid fog, used in the product Wonder Spray, does not appear to cause significant harm to lung health or blood metabolism, suggesting it is safe for use as a disinfectant. | - No detectable changes in blood metabolic panel after exposure to hypochlorous acid fog. - Minimal and likely reversible lung pathology observed. - Wonder Spray is considered safe for use as a disinfectant. - Potential for medical use in treating pneumonia and COVID-19. | This is from Journal in 2020 at https://www.scitechnol.com/peer-review/ten-day-exposure-to-hypochlorous-acid-wonder-spray-fog-results-in-no-detectable-effect-on-blood-metabolic-panel-and-minimal-lung-p-aAWv.php?article_id=13381 | |
This patent discusses a method for using low concentrations of hypochlorous acid solutions to effectively inhibit the activity of viruses and bacteria, providing a safe and versatile treatment option for various infectious diseases. | - Hypochlorous acid (HOCl) can inhibit the growth of various pathogens, including bacteria, viruses, fungi, and spores. - It is effective in treating infections and reducing antimicrobial resistance. - HOCl can be delivered through nebulizers, sprays, or oral rinses for respiratory and oral health applications. - The solution is safe and similar to what the body produces to fight infections. - The method of delivery can enhance treatment effectiveness by targeting specific areas directly. - HOCl solutions are approved for various medical uses, including eye and nasal infections. - The technology aims to provide a new approach to managing infectious diseases and improving health outcomes. | This is from Journal in 2024 at https://patents.google.com/patent/US20200281969A1/en | |
The inhalation of gaseous hypochlorous acid (HOCl(g)) at low concentrations, typically encountered during indoor disinfection, does not have a significant cytotoxic effect on human respiratory epithelial cells, according to a study using laboratory model systems. | - Inhalation of gaseous hypochlorous acid (HOCl(g)) at low concentrations (less than 500 ppb) has no cytotoxic effect on respiratory epithelial cells. - The concentration of HOCl(g) reaching the lung pseudo-space is close to zero when the chamber concentration is less than 20.5 ppb. - HOCl(g) adsorbs on gas-contact silicone rubber surfaces, leading to its disappearance during inhalation. | This is from J Microorg Control in 2023 at https://pubmed.ncbi.nlm.nih.gov/37394529/ This is from J Microorg Control in 2023 at https://pubmed.ncbi.nlm.nih.gov/38233168/ This is from Zhonghua Jie He He Hu Xi Za Zhi in 2024 at https://pubmed.ncbi.nlm.nih.gov/38309959/ This is from Natl Toxicol Program Tech Rep Ser in 1993 at https://pubmed.ncbi.nlm.nih.gov/12616290/ | |
Hypochlorous acid (HOCl) is a potent disinfectant with the potential to prevent infections and support healing, showing promise in medical applications, particularly during the COVID-19 pandemic. | - Hypochlorous acid (HOCl) is effective in killing pathogens and has applications in wound care and infection prevention. - It can cause tissue damage and health risks if not used properly, particularly in high concentrations. - HOCl has been approved by the FDA for various medical uses, including wound cleansing and as a sanitizer. - Studies show HOCl can enhance mucosal immunity and reduce viral loads, making it relevant for respiratory infections like COVID-19. - Its use in chronic wound care shows promise, outperforming traditional treatments in some cases. - Regulatory bodies recognize HOCl as safe for various applications, including food sanitation and medical disinfection. | This is from GMS Hyg Infect Control in 2023 at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10073986/ | |
Topical stabilized hypochlorous acid is a promising new treatment for improving wound healing and reducing scars after dermatologic and plastic surgery procedures. | - Topical stabilized hypochlorous acid (HOCl) is effective for wound care and scar management. - It helps reduce hypertrophic scars and keloids. - Provides a good environment for wound healing. - Combined with silicone, it may further reduce scarring. - Safer than chlorhexidine, with no concerns of ocular or ototoxicity. - Offers a powerful alternative to traditional wound care methods. | This is from Wiley Periodicals in 2020 at https://pubmed.ncbi.nlm.nih.gov/31904191/ | |
A cheap disinfectant spray made from hypochlorous acid could effectively kill viruses like Covid-19, but its widespread use in the UK has been slow due to bureaucratic delays and resistance to new ideas. | - Hypochlorous acid (HOCl) is a highly effective disinfectant, 100 times more effective than bleach. - It is non-toxic, cheap to produce, and safe for humans. - HOCl has been successful in curbing Covid-19 spread in countries like South Korea. - There is a push for wider use of HOCl in the UK, especially in public spaces and healthcare settings. - Fogging tunnels using HOCl could help prevent future spikes in infections. - The NHS is considering HOCl as a potential solution but requires further testing. | This is from Journal in 2023 at https://www.dailymail.co.uk/news/article-8558121/Spray-costs-pennies-kills-viruses-instantly-simple-solution-Covid-nightmare.html | |
A solution containing hypochlorous acid is effective in killing harmful bacteria and a virus similar to SARS-CoV-2, making it a promising option for reducing infection risk during dental procedures. | - Hypochlorous acid (HOCl) effectively inactivates oral pathogens and a SARS-CoV-2 surrogate. - HOCl solution is safe for tissues and can be used in dental practices. - Minimum inhibitory volume ratio is 4:1 without saliva and increases to 8:1 with saliva. - Higher concentrations of HOCl do not significantly improve efficacy against certain pathogens. - HOCl can be used as therapeutic water or mouthwash to reduce airborne infection risk in dental settings. | This is from Journal in 2023 at https://bmcoralhealth.biomedcentral.com/articles/10.1186/s12903-023-02820-7 | |
This study suggests that using a nasal rinse with hypochlorous acid can safely help reduce symptoms in COVID-19 patients who are not hospitalized. | - Intranasal lavage with hypochlorous acid can safely reduce COVID-19 symptoms in outpatient patients. - The study involved 88 patients, with 74 completing the treatment. - No serious adverse effects were reported; mild reactions included nasal burning and metallic taste. - The treatment showed feasibility and safety, but further research is needed for broader application. - No patients required hospitalization or mechanical ventilation. | This is from MedRxiv in 2023 at https://www.medrxiv.org/content/10.1101/2023.07.17.23292426v1.full | |
This patent describes a new formulation of shelf-stable hypochlorous acid that can be used to treat or prevent viral and bacterial infections, offering a potential solution for conditions like the common cold and chronic wounds. | - Hypochlorous acid (HOCl) can treat or prevent viral and bacterial infections. - It is effective in nasal sprays and wound care. - The composition is shelf-stable and can be made from lithium, calcium, or sodium hypochlorite. - HOCl works by killing microorganisms quickly and efficiently. - It helps in healing chronic wounds and reducing antibiotic resistance. - The product is designed to match the pH of the nasal cavity for better absorption. | This is from Journal in 2023 at https://patents.google.com/patent/US20230017920A1/en | |
This patent describes a stable cleaning solution that effectively sterilizes and cleans surfaces by generating hypochlorous acid and hypochlorite ions using a unique electrolysis method, making it safe and easy to produce for use in various settings, including dental care. | - Development of a stable cleaning solution with high hypochlorous acid concentration. - Effective against bacteria and viruses. - Produced using a diaphragm-free electrolysis process. - Residual chlorine concentration between 500 ppm to 2000 ppm. - pH range of 8.5 to 9.5 for stability. - Suitable for small-scale production in hospitals and dental clinics. - Enhances sterilizing ability when pH decreases during use. | This is from Journal in 2023 at https://patents.google.com/patent/US10194665B2/en | |
This patent describes a stabilized hypochlorous acid solution that can effectively prevent and treat infections during abdominal surgeries by using a unique combination of ingredients to enhance its antimicrobial properties. | - Antimicrobial solution includes hypochlorous acid, divalent cation, phosphate anion, and water. - Effective in treating/preventing infections during abdominal surgery. - Solution stable for extended periods, maintaining efficacy against bacteria. - Can be used in various surgical procedures like appendectomy and laparotomy. - Administered via abdominal lavage or directly to the abdominal cavity. | This is from Journal in 2023 at https://patents.google.com/patent/US20160120183A1/en | |
This patent describes a method for producing and storing hypochlorous acid solutions that remain effective for up to 24 months, making them useful for sanitizing surfaces and extending the life of cut flowers. | - Method for producing shelf-stable hypochlorous acid solutions. - Uses high purity water and electrolysis for production. - Improved shelf life when stored in opaque PET bottles. - Applications include sanitizers for food and non-food surfaces, cleaners, and cut flower life extenders. - Non-toxic nature makes it suitable for consumer use. - Extended shelf life of up to 24 months is achievable. | This is from Journal in 2023 at https://patents.google.com/patent/US20150119245A1/en | |
Topical stabilized hypochlorous acid is a powerful new antiseptic that can improve wound healing and reduce scarring, making it a promising option for doctors in wound care and plastic surgery. | - Topical stabilized hypochlorous acid (HOCl) is effective for wound care and scar management. - It has strong microbicidal and antibiofilm properties. - HOCl improves the healing environment and may reduce scarring when combined with silicone. - It poses no risks of ocular or ototoxicity compared to chlorhexidine. - Offers an alternative to less desirable wound care methods. | This is from Journal in 2023 at https://onlinelibrary.wiley.com/doi/10.1111/jocd.13280 | |
This document describes a new system for producing pure hypochlorous acid on-site, remotely controlled, and designed for various applications, addressing issues of stability and safety in traditional manufacturing methods. | - Deployable, remote-controlled system for manufacturing pure hypochlorous acid (HOCl). - Produces high potency, safe, and stable HOCl without contaminants. - Utilizes electrolysis with controlled water flow and feedback mechanisms. - Addresses global challenges like pandemics and water shortages. - Offers real-time monitoring and diagnostics via remote communication. - Designed for easy operation by untrained personnel. - Capable of producing clean drinking water alongside HOCl. | This is from Journal in 2023 at https://patents.google.com/patent/WO2022032115A2/en?assignee=briotech&oq=briotech | |
This patent describes a stable hypochlorous acid solution that remains effective for at least three months without the need for additional stabilizers, making it useful for disinfection in medical, agricultural, and food processing applications. | - Stable hypochlorous acid (HOCl) solution retains antimicrobial activity for at least three months. - Composition has low chloride levels and a pH between 3.5 and 7.0. - Suitable for sterilization in medical, agricultural, and food processing applications. - Non-toxic and non-mutagenic, making it safe for various uses. - Can be produced without the need for additional stabilizers. | This is from Journal in 2023 at https://patents.google.com/patent/CN103501605B/en?q=(stabilizing+HOCl)&oq=stabilizing+HOCl | |
This patent describes a stabilized solution of hypochlorous acid that is effective for disinfecting surfaces and treating wounds, offering a convenient and long-lasting alternative to traditional disinfectants. | - Stabilized hypohalous acid solutions are effective for disinfecting wounds, surfaces, and food products. - The solutions maintain stability over time, enhancing their commercial usability. - Incorporating bicarbonate improves the biocidal activity and stability of hypochlorous acid solutions. - The solutions are non-irritating and safe for human use, making them suitable for medical applications. - Hydrogel formulations of the solutions can be created for easier application and effectiveness. | This is from Journal in 2023 at https://patents.google.com/patent/US10576152B2/en?q=(stabilizing+HOCl)&oq=stabilizing+HOCl | |
This case series describes the use of hypochlorous acid as an adjuvant treatment for managing eye infections and blepharitis, showing that it can shorten the time to clinical resolution of these conditions. | - Hypochlorous acid can be used as an antiseptic washout to improve patient comfort after intravitreal injection. - Hypochlorous acid has been shown to be effective against endophthalmitis isolates of Staphylococci. - Hypochlorous acid can be used to reduce bacterial load on ocular skin. - Hypochlorous acid has been shown to improve symptoms in patients with dry eye. - Hypochlorous acid has been used as a skin antiseptic agent. - Hypochlorous acid has been shown to be effective against established biofilms. - Hypochlorous acid can be used to treat blepharitis and chalazia. - Hypochlorous acid has a neutral pH and disinfectant activity. - Hypochlorous acid has a good ocular safety profile in rabbits. | This is from Drugs in Context in 2022 at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267159/. | |
The use of hypochlorous acid as a wound cleanser has been found to be safe and effective in treating various types of pediatric and neonatal wounds, without causing any pain or discomfort. | - Hypochlorous acid (HOCl) is an effective antimicrobial wound cleanser that is noncytotoxic, nontoxic if absorbed percutaneously, effective in various forms, and painless on application. - HOCl is widely used in multiple medical applications, including in dental treatment as a mouth rinse and in ophthalmology as treatment for blepharitis. - The intact, undissociated pure HOCl-based product has an excellent safety profile in wound care. - A pure HOCl solution has been proven to have maximal antimicrobial preservative properties that exceed that of the hypochlorite species largely found in the Dakin’s solution and in products that have a pH higher than approximately 5.5. - HOCl has been utilized to eliminate biofilm in chronic wounds, as an effective instillation medium for negative pressure therapy and ultrasound therapy, and in general as a cleanser for wounds that contain debris or microbes. - HOCl is safe and efficacious in wound care for neonatal and pediatric patients. | This is from Wound Management & Prevention in 2023 at https://www.hmpgloballearningnetwork.com/site/wmp/article/hypochlorous-acid-pediatric-wound-management-cleansing-healing-wounds | |
In vitro experiments showed that hypochlorous acid (HOCl) solutions can be effective in inactivating avian influenza virus (AIV) in liquid and spray forms, providing a possible method for controlling AIV at the farm level. | • Sprayed hypochlorous acid solutions showed virucidal activity against avian influenza virus in in vitro experiments. • The use of electrolyzed water in the food industry has been studied and found to be effective. • Common detergents and chemicals can inactivate avian influenza virus. • Biocides have viricidal activity and specific mechanisms of action. • Chlorine has been shown to inactivate highly pathogenic avian influenza virus. • Factors such as physico-chemical conditions and surfaces can affect the survival of avian influenza virus. • Passive immunization with antiserum generated from viral polypeptides can protect poultry birds from lethal avian influenza virus infection. • Acidic electrolyzed water and neutral electrolyzed water have a virucidal effect on avian influenza viruses. • The persistence of avian influenza viruses in frozen environmental water types has been studied. • The onset of virus shedding and clinical signs in chickens infected with avian influenza viruses has been investigated. • DIVA vaccination strategies for avian influenza virus have been explored. • The occurrence and transmission characteristics of airborne avian influenza virus have been studied. • Low-pathogenicity avian influenza virus can be transmitted from chickens to other bird species. • Membraneless acidic electrolyzed water has antimicrobial effects on airborne bacteria from poultry houses. | This is from Journal of Veterinary Medical Science in 2015 at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363024/. | |
This study found that hypochlorous acid (HOCl) solution, which can be generated from electrolysis of 3% hydrochloric acid, is effective against oral pathogens and a SARS-CoV-2 surrogate virus even in the presence of saliva and after passing through the dental unit water line, showing promise as a potential supplement to water and/or mouthwash to reduce the risk of airborne infection in dental practice. | - Hypochlorous acid can inactivate oral pathogens and a surrogate of SARS-CoV-2. - Hypochlorous acid has potential as a wound care agent. - Hypochlorous acid has been shown to be effective against avian influenza viruses and human norovirus. - The volume of mouthwash for rinsing can be determined for comfortable use. | This is from BMC Oral Health in 2021 at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938691/. | |
This study investigated the efficacy of hypochlorous acid (HOCl) in inactivating a surrogate for SARS-CoV-2 on surfaces frequently encountered in consumer-facing environments, finding that increased HOCl concentration and exposure time led to increased reduction of the surrogate, but that the highest estimated mean log reduction may not adequately reduce enveloped viruses to below infective thresholds. | - Hypochlorous acid can be effective in inactivating a SARS-CoV-2 surrogate on surfaces, but the effectiveness can be impacted by various factors such as surface type, contact time, inoculum matrix, and concentration. - There are various sanitizing agents that can be used for virus inactivation and disinfection, but their efficacy can depend on the specific virus and the conditions of use. - The stability of SARS-CoV-2 on surfaces can be impacted by factors such as temperature and humidity. - There are various methods for assessing the virucidal activity of chemical germicides, such as a disc-based quantitative carrier test method. - Low concentration hydrogen peroxide vapor can be effective in inactivating MS2 bacteriophage and the presumed Ebola virus surrogate Phi6. | This is from Food Environ Virol in 2023 at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862229/. | |
This study found that hypochlorous acid (HOCl) solution, which can be generated from electrolysis of hydrochloric acid, is effective against common human oral pathogens and a SARS-CoV-2 surrogate virus, even in the presence of saliva and after passing through dental unit water lines. This suggests that HOCl solution could be used as a supplement to water and/or mouthwash to reduce the risk of airborne infection in dental practice. | - Hypochlorous acid can inactivate oral pathogens and a surrogate for SARS-CoV-2. - Hypochlorous acid has potential applications in wound care and disinfection. - Electrolyzed water can produce hypochlorous acid. - There are several studies evaluating the effectiveness of hypochlorous acid against viruses and bacteria. - Saliva plays a role in maintaining a healthy oral microbiota. | This is from BMC Oral Health in 2021 at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938691/. | |
This study found that hypochlorous acid (HOCl) at a concentration of 100 ppm can effectively and rapidly destroy COVID-19, influenza, and herpes viruses that are spread through saliva and droplets, making it a potentially effective virucide for use in dental procedures to prevent transmission of these viruses. | - HOCl can rapidly kill Corona, Flu, and Herpes to prevent aerosol spread. - Saliva can be used as a diagnostic material for influenza virus infection by PCR-based assays. - Preprocedural mouthrinses can reduce SARS-CoV-2 load in dental aerosols. - The airborne lifetime of small speech droplets is important in SARS-CoV-2 transmission. - Disinfection and sterilization are important in healthcare facilities to prevent the spread of infections. - Aerosol transmission is a possible route for influenza A virus. - The evolutionary trajectory of SARS-CoV-2 and emerging variants is being studied. - Hypochlorous acid can be used as a disinfectant for dental unit waterlines. - Free radicals have implications in various diseases. - The pathology of influenza virus infections has been studied. - Herpes simplex virus has a global infection prevalence and incidence estimates. - The future of knowledge representation and creative work aided by machine understanding of language is being investigated. | This is from Journal in 2023 at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10227542/. | |
This article discusses the effects of hypochlorous acid (HOCl) on mammalian cells, including its role in killing pathogens and its potential to cause tissue injury and inflammation. It also explores how HOCl interacts with different cell components and describes the outcomes of exposure to different doses of HOCl. The article concludes by highlighting recent research indicating that HOCl may activate cell signaling pathways, providing important information on the role of this oxidant in inflammation. | - Hypochlorous acid (HOCl) is a reactive oxidant produced by the immune system to kill invading pathogens. - HOCl can also damage mammalian cells, including proteins, lipids, and DNA. - Exposure to HOCl can lead to cell death, apoptosis, or growth arrest. - HOCl has been implicated in various diseases, including atherosclerosis and inflammatory bowel disease. - Researchers have studied the effects of HOCl on different types of cells, including red blood cells, endothelial cells, and heart muscle cells. | This is from IUBMB Life in 2000 at https://iubmb.onlinelibrary.wiley.com/doi/10.1080/713803731. | |
This article explores the effects of hypochlorous acid, generated by neutrophils, on both the host and pathogens in the body. | - Neutrophils are immune cells that produce hypochlorous acid (HOCl) and other hypohalous acids (HA). - HOCl and HA are toxic to pathogens, but can also damage host tissues. - The effects of HOCl and HA depend on their concentration and the context in which they are produced. - Understanding the balance between the beneficial and harmful effects of HOCl and HA can help develop new therapies for infectious and inflammatory diseases. | This is from SpringerLink in 2020 at https://link.springer.com/article/10.1007/s00018-020-03591-y | |
This study investigated the effectiveness of dry fogging hypochlorous acid and hydrogen peroxide solutions in inactivating SARS-CoV-2 and influenza A virus on environmental surfaces, finding that higher concentrations and longer contact times of the disinfectants were required to inactivate SARS-CoV-2 than influenza A virus. The results provide important information for the development of strategies to control the transmission of these viruses in public spaces. | - Dry fogging of hypochlorous acid solution and hydrogen peroxide solution effectively inactivated SARS-CoV-2 and influenza A virus that had been adhered to plastic microplates. - Dry fogging is an active countermeasure against infection sources on environmental surfaces. - Dry fogging is expected to act effectively not only against the Wuhan strain and H1N1 strain tested in the present study, but also against other virus strains. - It is important to examine whether dry fogging of disinfectants inactivates viruses in a space. | This is from PLoS ONE in 2022 at https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0261802. | |
Hypochlorous acid wound care is a safe and effective solution for managing various afflictions in animals, providing gentle care and promoting good hygiene without any side effects. | - HOCl is a naturally occurring chemical found in the bodies of living organisms. - HOCl is the primary active ingredient in Clireon's Wound Care & Skin Care spray and gel. - HOCl can provide gentle, effective care to help manage sores, cuts, abrasions, burns, hot spots, skin irritations, saddle wounds, and post-surgical wounds. - HOCl is safe for use on all animals. - HOCl is highly effective in combating the symptoms of dry skin in dogs. - HOCl is effective in managing infections in animals. - HOCl is fast-acting and can kill microorganisms on the wound or infection within 30 seconds of application. - HOCl is a practical, all-natural, and environmentally-friendly alternative for animal care. | This is from Clireon in 2023 at https://www.clireon.com/blogs/animal-care-tips/top-10-benefits-of-hypochlorous-acid-wound-care. | |
This thesis explores the potential of on-site production of hypochlorous acid for disinfection applications, including wastewater treatment and sanitization of dental operating rooms. | - Hypochlorous acid (HOCl) is a powerful disinfectant that can be easily produced from the electrolysis of sodium chloride. - HOCl has a wide variety of applications, including wound care, eye care, pet care, horticulture, and wastewater treatment. - An on-site chlorination generator was fabricated and integrated into the Biddeford Pool Wastewater Treatment Plant in December 2022. - A finite element model was developed to predict room coverage with HOCl fog as a function of carrier gas velocity and position for the removal of airborne pathogens in a dental clinic by fogging. - The model should estimate the fogging time and concentration to disinfect a room. - The next step would incorporate a kinetic model for HOCl fog destruction including reaction and evaporation. | This is from Electronic Theses and Dissertations in 2023 at https://digitalcommons.library.umaine.edu/etd/3775. | |
This study found that hypochlorous acid fogging can effectively sanitize surfaces against Enterococcus faecalis, a persistent source of infection, with continuous fogging being the most effective method of application. | - Fogging with hypochlorous acid (HOCl) is an efficient method for disinfecting large areas. - Ultrasonic fogging with continuous application is the most effective mode of application for HOCl fogging against Enterococcus faecalis. - The optimal pulsed fogging protocol produced a similar reduction, but required nearly 5 times as long. - The home synthesized versions of HOCl yielded much lower log bacterial reductions. - No significant differences in outcome were determined between polymer or metal surfaces. | This is from ScienceDirect in 2022 at https://www.sciencedirect.com/science/article/abs/pii/S019665532200150X. | |
Hypochlorous acid is a weak acid that is an oxidizer and primary disinfectant agent in chlorine solutions, with a history of use in medicine, wound care, and disinfection, and is still being studied for potential uses in water treatment, organic synthesis, and deodorization. | - Hypochlorous acid is a potent disinfectant that can inactivate many vital systems in bacteria in less than 0.1 seconds. - The concentration required for bactericidal activity is highly dependent on bacterial concentration. - Hypochlorous acid can cause inhibition of glucose oxidation, depletion of adenine nucleotides, inhibition of DNA replication, and protein unfolding and aggregation. - Hypochlorous acid water is difficult to maintain as it quickly deteriorates back into salt water, losing its disinfecting capability. | This is from Wikipedia in 2021 at https://en.wikipedia.org/wiki/Hypochlorous_acid | |
Hypochlorous acid solutions, made from electrolyzed water, are a highly effective and safe approach to wound care for animals, as they eradicate dangerous organisms while not causing harm to cells. | - Hypochlorous acid solutions are a recent and highly effective approach to wound care. - Hypochlorous acid solutions are non-toxic to the delicate cells that heal wounds, while being lethal to almost all known dangerous bacteria and viruses that threaten health. - Hypochlorous acid also exists in the form of a hydrogel, which makes it ideal as a wound filler. - Sea salt used in HOCl solutions should be rich in minerals, containing all 84 essential trace elements that are also present in the human body. | This is from IVC Journal in 2023 at https://ivcjournal.com/hypochlorous-acid-solutions/. | |
This article discusses the role of hypochlorous acid in periodontal disease, highlighting its potential as an antimicrobial and inflammation-modulating medication. ROS, including hypochlorous acid, play a complex role in the immune response to pathogens in periodontitis, and their regulation is crucial in treating the disease. | - Hypochlorous acid (HOCl) can modulate the inflammatory response and may have both proinflammatory and anti-inflammatory characteristics. - TauCl possesses mostly anti-inflammatory properties and may promote healing and alleviate inflammation. - The Periodontal Department of Taipei Medical University Hospital began using an ultrasonic spray of HOCl for constant sterilization and infection control of clinical cubicles and wound irrigation during periodontal surgery in 2007. | This is from Journal of Dental Sciences in 2010 at https://www.sciencedirect.com/science/article/pii/S1991790209600088. | |
The article discusses the potential use of a prefabricated sanitizing chamber that uses hypochlorous acid as a disinfectant in the fight against COVID-19, and explores the efficacy and safety of hypochlorous acid as a disinfectant. | - Hypochlorous acid can be effective in disinfecting surfaces and reducing bacterial load. - A smart prefabricated sanitizing chamber can reduce exposure to COVID-19 in occupational settings. - Short-term skin reactions can occur from using N95 respirators and medical masks. - There is a need for more effective methods for cleaning and disinfecting enclosed spaces. - The future of disinfection may involve the use of slightly acidic electrolyzed water. | This is from Risk Management and Healthcare Policy in 2023 at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837568/. |