Summary
A small first-in-human trial found a hypochlorous acid and acetic acid wound solution safe and well tolerated in chronic leg ulcers, with lower bacterial counts than saline after treatment.
Key points
- 20 patients had a single dose of the solution (16) or saline (4); 8 more had it once or twice daily for five days.
- The solution was safe and well tolerated, and pain did not differ from saline.
- Median bacterial load fell 98% after the solution and 49% after saline.
- Wound size fell in a dose-related trend in the multiple-dose group.
- The product combines hypochlorous acid with acetic acid; it is not plain hypochlorous acid. A phase 1 study with few patients.