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Bactericidal and cytotoxic effects of sodium hypochlorite and sodium dichloroisocyanurate solutions in vitro

PubMed · added Oct 2026

Summary

In laboratory tests, sodium dichloroisocyanurate (NaDCC) and sodium hypochlorite killed oral bacteria at similar strengths, and both harmed human fibroblasts (connective-tissue cells) at similar strengths.

Key points

  • Minimum inhibitory and bactericidal concentrations of NaDCC and sodium hypochlorite were in a similar range for four oral bacteria, including Enterococcus faecalis.
  • NaDCC above 0.02% and sodium hypochlorite above 0.01% were lethal to human fibroblasts in culture.
  • The authors concluded that the two agents kill bacteria well and have similar cytotoxicity to fibroblasts.
  • A laboratory study of cells in culture, not a study in people or in wounds.