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Comparative Antimicrobial Activity of Commercial Wound Care Solutions on Bacterial and Fungal Biofilms

PMC · added Oct 2026

Summary

In laboratory tests, two hypochlorous acid wound solutions (Vashe and PhaseOne) cleared most bacterial and fungal biofilms within 1 to 10 minutes, while mafenide acetate (Sulfamylon) largely did not.

Key points

  • Biofilms of 66 strains of Gram-negative bacteria, Gram-positive bacteria and Candida were tested.
  • Vashe and PhaseOne eliminated all biofilms except Candida albicans at 1 or 10 minutes.
  • Mafenide acetate (Sulfamylon) could not eliminate most biofilms, even after 24 hours.
  • A laboratory study, not a study in people.