Summary
Troclosene sodium, also called sodium dichloroisocyanurate (NaDCC), is a chlorine compound that releases hypochlorous acid in water. Israel withdrew its license as a wound irrigation solution in 2006 over safety questions. In this study, 30 patients with 35 infected skin wounds of various causes and body areas were treated with the solution for 8 days. There were no adverse clinical events and no abnormal laboratory tests. Pain, swelling, exudate, redness and the area covered by new granulation tissue all improved significantly, and bacteria were found in 90% of wound samples before treatment and 40% on day 8. Serum sodium rose, and urea and several blood cell counts fell, but all stayed within normal ranges. The authors concluded the solution is clinically safe for infected wounds, and the findings led Israel's Ministry of Health to re-approve it. The abstract describes no comparison group.