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Research

Effect of Stabilized Hypochlorous Acid on Re-epithelialization and Bacterial Bioburden in Acute Wounds: A Randomized Controlled Trial in Healthy Volunteers

PMC · added Oct 2026

Summary

In 20 healthy volunteers with small blister wounds on each forearm, a stabilized hypochlorous acid solution speeded early skin regrowth and lowered bacterial counts compared with saline.

Key points

  • Each of 20 volunteers had one blister wound per forearm, randomly treated with the solution or saline on days 0, 2 and 4.
  • Re-epithelialization on day 4 was 14% higher with the solution; by day 10 the two were equivalent.
  • Median bacterial counts were lower with the solution and stayed lower than with saline.
  • Healthy volunteers with small experimental wounds, so it does not show the effect on chronic or infected wounds.