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Research

High-Efficiency Particulate Air Filters to Prevent Winter Respiratory Infections in Care Homes: The AFRI-c Cluster Randomized Clinical Trial

doi.org · added Oct 2026

Summary

In 91 English care homes, portable HEPA filters in communal rooms and bedrooms made no detectable difference to respiratory infections per resident per winter (0.99 vs 1.04; adjusted rate ratio 0.92, 95% confidence interval 0.64 to 1.33) or to staff absence, with both groups keeping their usual infection prevention measures.

Key points

  • Respiratory infections per resident per winter were 0.99 with HEPA filters and 1.04 without (adjusted rate ratio 0.92, 95% confidence interval 0.64 to 1.33), with no evidence of a difference.
  • Staff absence also did not differ (adjusted rate ratio 0.80, 95% confidence interval 0.55 to 1.16).
  • Results were similar for residents exposed only to filters in communal rooms.
  • Both groups kept their usual infection prevention measures.
  • Design: cluster randomized trial in 91 English care homes, each for one winter, 2021 to 2024; residents' median age was about 87.