A study comparing the effectiveness of hypochlorous acid (HOCl) nasal irrigation to saline nasal irrigation in reducing allergic rhinitis (AR) symptoms found that both groups showed improvement in symptoms, but there were no significant differences between the two groups. HOCl did not show any additional improvement in symptoms compared to saline nasal irrigation for patients with perennial AR.
- Low-concentration hypochlorous acid (HOCl) nasal irrigation can help reduce allergic rhinitis symptoms. - HOCl has antipruritic, anti-inflammatory, and antimicrobial effects without toxicity. - HOCl nasal irrigation did not show additional improvement in symptoms compared with saline nasal irrigation for patients with perennial allergic rhinitis. - The study was multicenter, randomized, double-blind, and placebo-controlled. - The study involved 139 patients with perennial allergic rhinitis, but 25 did not successfully complete the study. - Participants completed the Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) at every visit, and Total Nasal Symptom Score (TNSS) was determined before and after nasal irrigation every morning and evening. - There were no significant differences in the change of TNSS between the HOCl and saline groups. - The HOCl group did not show any clinical side effects related to nasal irrigation.
This is from PubMed in 2023 at https://pubmed.ncbi.nlm.nih.gov/34236253/.
Top Five Keywords: allergic rhinitis, hypochlorous acid, nasal lavage, randomized controlled trial, adult.
Abstract
Background: Low concentrations of hypochlorous acid (HOCl) have proven antipruritic, anti-inflammatory, and antimicrobial effects without toxicity, although the mechanism has not been fully elucidated.
Objective: The aim of this study was to evaluate the effectiveness of HOCl nasal irrigation to reduce allergic rhinitis (AR) symptoms compared with saline nasal irrigation.
Methods: This was multicenter, randomized, double-blind, placebo-controlled study. Initially, 139 patients with perennial AR were enrolled; however, 25 did not successfully complete the study. Patients were randomly assigned to the nasal irrigation with low-concentration HOCl (n = 55) or normal saline (n = 59) treatment groups for the 4-week study period. Participants completed the Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) at every visit (baseline, Weeks 2 and 4), and Total Nasal Symptom Score (TNSS) was determined before and after nasal irrigation every morning and evening.
Results: We found that RQLQ scores significantly decreased after 4 weeks in the HOCl and placebo groups, but the decrement of the RQLQ score was similar between the 2 groups. Additionally, TNSS improved in both groups between baseline and Week 4, whereas there were no significant differences in the change of TNSS between the 2 groups. The HOCl group did not show any clinical side effects related to nasal irrigation.
Conclusion: Allergic symptoms significantly decreased with low-concentration HOCl nasal irrigation, without significant adverse events. However, HOCl showed no additional improvement in symptoms compared with saline nasal irrigation for patients with perennial AR.
Keywords: adult; allergic rhinitis; hypochlorous acid; nasal lavage; randomized controlled trial.