Summary
A preprint pooling 29 studies ranked sodium hypochlorite and hypochlorous acid solutions first for wound healing among antiseptics compared with saline, though the ranking comes from indirect comparisons and has not been peer reviewed.
Key points
- 29 studies were included (22 randomized trials and 7 cohort studies) from 507 records found in PubMed and Scopus.
- Sodium hypochlorite and hypochlorous acid solutions had a 1.07 to 1.30 times higher chance of wound healing than the other regimens.
- They ranked first, followed by silver, octenidine and polyhexanide.
- Compared were povidone-iodine, octenidine, polyhexanide, alcohol and silver against normal saline.
- A preprint, not yet peer reviewed. A network meta-analysis relies on indirect comparisons across studies of mixed quality.