Summary
A 12-person pilot found a hypochlorous acid and acetic acid wound irrigation safe and well tolerated on skin graft donor sites, though treatment was often painful, and lab tests showed activity against biofilms.
Key points
- 12 people having skin grafts were treated on the donor site for 75 seconds on 6 occasions.
- Seven adverse events were related to treatment, all pain during the procedure in 2 people; one donor site became infected.
- Mean bacterial counts fell 41%, and the wounds were about 96% re-epithelialized on days 14 and 21.
- In the lab, a 15-minute treatment cut Pseudomonas aeruginosa biofilm counts 96% and Staphylococcus aureus 50% (not statistically significant).
- A small open-label pilot with no comparison group.